Indirubin -- Component Of Chinese herbal remedy might block brain tumor's spread
- When human glioblastoma cells were transplanted into one brain hemisphere of mice, indirubin-treated animals survived significantly longer than controls and showed no migration of tumor cells to the opposite hemisphere.
- In a separate experiment, indirubin reduced the migration of tumor cells by 40 percent in treated animals versus controls.
- Treated tumors showed a lower density of blood vessels, and new blood-vessel growth was reduced up to three-fold in intracranial tumors, depending on the tumor-cell line.
- A laboratory assay showed that indirubins reduced endothelial-cell migration by 52 to 41 percent compared with untreated controls.